Table 3.
Clinical and biochemical differences between subclinical and overt hypothyroidism.
| Subclinical Hypothyroidism (n = 28) | Overt Hypothyroidism (n = 64) | p Value | |
|---|---|---|---|
| Age (years) | 51 (30–68) | 52 (41–63) | 0.61 |
| BMI (kg/m2) | 26.3 (24.2–30.4) | 25.9 (24.3–31.2) | 0.99 |
| Doses of levothyroxine for thyroid profile normalization (mg/day) | 68 (50–100) | 100 (75–150) | 0.006 * |
| TSH before therapy (mIU/L) | 12.2 (9.8–43.5) | 47.5 (10.9–74.9) | 0.001 * |
| TSH at treatment (mIU/L) | 1.07 (0.9–3.2) | 1.3 (1.0–3.4) | 0.12 |
| FT4 before therapy (pg/mL) | 1.3 (0.9–1.6) | 0.52 (0.15–0.71) | 0.02 * |
| FT4 at treatment (pg/mL) | 1.01 (0.94–1.2) | 1.1 (0.99–1.19) | 0.88 |
| FSS score before levothyroxine | 31 (26–45) | 33 (16–51) | 0.99 |
| FSS score at treatment | 24 (20–33) | 18 (11–36) | 0.37 |
Quantitative variables were reported as median and interquartile range. BMI: body mass index; TSH: thyroid stimulating hormone; FT4: free thyroxine; FSS: fatigue severity scale. * p > 0.05 = statistical significance.