Skip to main content
. 2023 Mar 3;12(3):625. doi: 10.3390/antiox12030625

Figure 2.

Figure 2

Verapamil enhances cell death induced by everolimus. (A) Plots of specific cell death assessed by PI staining in T-ALL cell lines treated for 24 h with verapamil (VER, 20 ng/mL), everolimus (EVE, 10 µM), or with both drugs. (B) Plots of specific cell death induced by a 24-h treatment with VER (20 ng/mL), EVE (10 µM), or both drugs in five T-ALL PDX, primary tumor cells from T-ALL patients (N = 7), and three preparations of normal thymocytes; mean values and standard error bars are shown. The indicated pairwise comparisons were statistically significant with the Mann-Whitney test; *** indicate p values < 0.001, ** < 0.01. (C) Combinatory effects of EVE and VER on T-ALL cells. Shown are Combenefit-generated surface maps for drug combinations in T-ALL cell lines. The axes indicate concentrations of each drug.