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ROS, mRNA expression of fibronectin and TGF-β1 in mouse M1 collecting duct cell line treated with high glucose (HG) with or without GKT 137831 (GKT) treatment. (A) Effect of NOX-4 inhibition on ROS generation and transcript levels of fibronectin (B) and TGF-β1 (C) in M-1 collecting duct cell line. GKT 137831 partially blunted ROS induction and increased mRNA levels of fibronectin and TGF-β1. * p < 0.05, n = 6.
