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. 2023 Mar 16;15(6):1792. doi: 10.3390/cancers15061792

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NKG2D expression associates with an IFNγ response and the expression of inhibitory immune checkpoint markers. (a) Survival probability in patients expressing high (red) vs. low (teal) levels of KLRK1. (b) Correlation between an IFNγ signature (left) and an NK/ILC1 signature (right) and KLRK1 expression. (c) Survival probability in patients with a high (red) vs. low (teal) IFNγ signature. (d) Correlation between PD-1 (PDCD1) (left) and PD-L1 (CD274) (right) and KLRK1 in colorectal cancer patients. COAD = Colon Adenocarcinoma, GSEA = gene set enrichment analysis, HR = hazard ratio. Statistical significance was determined using Log-rank (Mantel-Cox) and Mantel-Haezenszel test comparing upper and lower percentile (a,c) and linear regression analysis (b,d).