Figure 1.

Eye appearance and follow-up evolution of the 5 patients with more severe ocular manifestations. A–D, Patient 1, who demonstrated significant conjunctivitis at presentation (A) and showed geographical corneal ulcers (B) that evolved to severe thinning 8 days later (C). One week after Tecovirimat administration, the corneal lesions started to improve, with healing 1 month after presentation (D). E–H, Patient 2, who demonstrated eyelid papules (E) and membranous conjunctivitis with focal conjunctival erosions in the left eye (F) that extended over time and closed after 2 weeks of treatment with povidone–iodine and oxytetracycline plus polymyxin plus hydrocortisone ointment. Twenty days after initially seeking treatment, he demonstrated corneal involvement with semilunar corneal ulceration and Dellen (G) that infiltrated in the ensuing 5 days with stromal corneal edema (H). I–K, Patient 3, who showed eyelid papules (I) and membranous and mucopurulent conjunctivitis and conjunctival erosions (J) that were resolved 28 days after presentation (K). L–N, Patient 6, who demonstrated severe unilateral eyelid edema (L) and membranous conjunctivitis (M). Three days after presentation, he demonstrated cellulitis with restriction of the medium rectus and was admitted (N). O–Q, Patient 9 with peripheral corneal semilunar infiltrates (O, P) that evolved to corneal thinning with stromal edema (Q).