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. 2023 Mar 6;13(3):486. doi: 10.3390/biom13030486

Table 1.

A summary table of the impact on SELENOF in various cancers is included.

Cancer Model Phenotype Reference(s)
Prostate Cancer

  • Microarray

  • Serum selenium levels

  • Genotyping

  • SELENOF knockdown

 ↓SELENOF correlates to increased cancer progression [38,50,60]
Breast Cancer

  • The Cancer Genome Atlas data

  • SELENOF overexpression

  • SELENOF knockdown

  • Selenof KO mice

 ↓SELENOF correlates to increased proliferation and decreased cell death [62]
Colorectal Cancer

  • SELENOF knockdown

  • Selenof KO mice

 ↓SELENOF correlates to decreased proliferation and aberrant crypt formation [64,65,66,67]
Malignant Mesothelioma

  • SELENOF knockdown

  • Selenium supplementation

  • Genotyping

  • Patient samples

 Effectiveness of selenium supplementation dependent on polymorphism [63]

Arrow: Indicates reduced levels.