Figure 2.

Role of the BAFF-APRIL system in the development of hematological cancers. Dysregulated BAFF-APRIL signaling primarily contributes to the proliferation and survival of cancer cells, outlined in this schematic, with the mechanisms of action described in the relevant sections. Abbreviations: B-ALL = B-cell acute lymphoblastic leukemia; GC B cells = germinal center B cells; HRS cells = Hodgkin and Reed–Sternberg cells; HL = Hodgkin’s lymphoma; PC = plasma cells; MM cells = multiple myeloma cells; Fo B cells = follicular B cells; Burkitt’s Lymphoma; CLL = chronic lymphocytic leukemia; MBL = monoclonal B-cell lymphocytosis; TME = tumor microenvironment; CNSL = central nervous system lymphoma; DLBCL = diffuse large B-cell lymphoma; FL = follicular lymphoma; HCL = hairy cell leukemia; MCL = mantle cell lymphoma; MZL = marginal zone lymphoma. ↑ refers to upregulation and ↓ refers to downregulation.