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. 2023 Mar 9;15(6):1681. doi: 10.3390/cancers15061681

Figure 3.

Figure 3

Alterations in OCR, pro-inflammatory cytokines and metabolites in adipose explants from OAC patients correlates with previous treatment exposure (A) OCR, ECAR, and OCR:ECAR ratio (Kruskal–Wallis with Dunn’s correction). (B) IL-12p40, IL-1α, IL-22, IL-7, TNF-β, and VEGF-C (Kruskal–Wallis with Dunn’s correction). (C) Cer(d16:1/22:0), DCA, GUDCA, p-Cresol-SO4, Hex2Cer(d18:1/14:0), Hex3Cer(d18:1/24:1), SM (OH) C22:1, TG(14:0_36:2), and TG(16:0_33:2), TG(16:0_30:2) (Kruskal–Wallis with Dunn’s correction). (D) TG(16:0_34:3), TG(16:0_40:6), TG(16:1_34:1), TG(16:1_36:4), TG(16:1_36:5), TG(18:0_36:3), TG(18:2_35:2), TG(18:3_32:1), and TG(20:2_34:4) (Kruskal–Wallis with Dunn’s correction). (E) Correlation plot showing only significant correlations (p < 0.05) between experimental data and with neo-adjuvant treatment, chemotherapy only, chemo-radiotherapy differentiation, lymph involvement, venous involvement, and perineural involvement (Spearman correlation, blue indicates positive correlations and red indicates inverse negative correlations). The Holm–Bonferroni post hoc correction was used to control for multiple comparison testing. All data expressed as mean ± SEM, Naïve n = 10, FLOT n = 14, CROSS = 8, * p < 0.05, ** p < 0.01.