Figure 1.
General structure and topologies of G-quadruplexes (G4). (A) Representation of a G-quartet stabilized by Hoogsteen hydrogen bonds (left). Schematic representation of a G-quadruplex additionally stabilized by π-π interactions and monovalent cations (right). (B) Schematic illustration of different intra- and intermolecular G4 topologies with different guanosine conformations (syn and anti).