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Nrf2 protein structure. Nrf2 has seven Neh domains: Neh1 domain containing bZip regions. ETGE and DLG motifs, on Neh2, are the sequences through which Keap1 binds to Nrf2. The Neh3 domain contains nuclear localization sequences. Neh4 and Neh5 are transactivation domains and are bound by a ubiquitin ligase, such as Hrd1. On Neh6, DSGIS and DSAPGS motifs are used by βTrCP ubiquitin ligase. Finally, through the Neh7 domain, Nrf2 interacts with RXRα protein, inducing Nrf2 repression.
