Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1992 Mar;51(3):326–329. doi: 10.1136/ard.51.3.326

Skin rashes and stomatitis due to parenteral treatment of rheumatoid arthritis with sodium aurothiomalate.

A Svensson 1, J Theander 1
PMCID: PMC1004653  PMID: 1533505

Abstract

In a prospective study of 45 patients with rheumatoid arthritis mucocutaneous symptoms and signs were evaluated before and during treatment with intramuscular sodium aurothiomalate (Myocrisin). The work, performed in close collaboration between dermatology and rheumatology departments, showed that there was no significant increase in mucocutaneous side effects in patients with pre-existing mucocutaneous disease. It is concluded that pre-existing dermatitis is not a contraindication for treatment with gold salts and that a previous mucocutaneous reaction to gold salts is not an absolute contraindication for a new trial of chrysotherapy.

Full text

PDF
326

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOGG A. Skin complications of gold treatment. Acta Rheumatol Scand. 1958;4(2):86–97. doi: 10.3109/rhe1.1958.4.issue-1-4.11. [DOI] [PubMed] [Google Scholar]
  2. Bluhm G. B. The mechanisms of action of conventional chrysotherapy. J Rheumatol Suppl. 1982 Jul-Aug;8:10–17. [PubMed] [Google Scholar]
  3. Bretza J., Wells I., Novey H. S. Association of IgE antibodies to sodium aurothiomalate and adverse reactions to chrysotherapy for rheumatoid arthritis. Am J Med. 1983 Jun;74(6):945–950. doi: 10.1016/0002-9343(83)90787-8. [DOI] [PubMed] [Google Scholar]
  4. Caspi D., Tishler M., Yaron M. Association between gold induced skin rash and remission in patients with rheumatoid arthritis. Ann Rheum Dis. 1989 Sep;48(9):730–732. doi: 10.1136/ard.48.9.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gibbons R. B. Complications of chrysotherapy: a review of recent studies. Arch Intern Med. 1979 Mar;139(3):343–346. [PubMed] [Google Scholar]
  6. Glenert U. Drug stomatitis due to gold therapy. Oral Surg Oral Med Oral Pathol. 1984 Jul;58(1):52–56. doi: 10.1016/0030-4220(84)90364-5. [DOI] [PubMed] [Google Scholar]
  7. Klinefelter Reinstitution of gold therapy in rheumatoid arthritis after mucocutaneous reactions. J Rheumatol. 1975 Mar;2(1):21–27. [PubMed] [Google Scholar]
  8. Penneys N. S., Ackerman A. B., Gottlieb N. L. Gold dermatitis. A clinical and histopathological study. Arch Dermatol. 1974 Mar;109(3):372–376. doi: 10.1001/archderm.109.3.372. [DOI] [PubMed] [Google Scholar]
  9. Pinals R. S., Masi A. T., Larsen R. A. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum. 1981 Oct;24(10):1308–1315. doi: 10.1002/art.1780241012. [DOI] [PubMed] [Google Scholar]
  10. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  11. Rainer F. Unerwünschte Wirkungen der Goldtherapie. Wien Klin Wochenschr Suppl. 1984;156:40–44. [PubMed] [Google Scholar]
  12. Sigler J. W. Parenteral gold in the treatment of rheumatoid arthritis. Am J Med. 1983 Dec 30;75(6A):59–62. doi: 10.1016/0002-9343(83)90475-8. [DOI] [PubMed] [Google Scholar]
  13. Thomas I. Gold therapy and its indications in dermatology. A review. J Am Acad Dermatol. 1987 Apr;16(4):845–854. doi: 10.1016/s0190-9622(87)70111-x. [DOI] [PubMed] [Google Scholar]
  14. Van den Haute V., Antoine J. L., Lachapelle J. M. Histopathological discriminant criteria between lichenoid drug eruption and idiopathic lichen planus: retrospective study on selected samples. Dermatologica. 1989;179(1):10–13. doi: 10.1159/000248091. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES