Table 3.
Prophylactic Premedications for Infusion-Related Reactions and Antiemetics [8].
| Required Premedications | |||
|---|---|---|---|
| Medication | Dose and Route of Administration | Dosing Window Prior to Drug Administration | Cycle/Day |
| Glucocorticoid a | Dexamethasone 10 mg IV or Methylprednisolone 40 mg IV | 45 to 60 min | Cycle 1 day 1 and cycle 1 day 2 only |
| Antihistamine b | Diphenhydramine 25–50 mg | IV, 15 to 30 min PO, 30 to 60 min |
All cycles |
| Antipyretic b | Acetaminophen 650–1000 mg | IV, 15 to 30 min PO, 30 to 60 min |
All cycles |
| Optional Premedications | |||
| Glucocorticoid a | Dexamethasone 10 mg or Methylprednisolone 40 mg | IV, 45 to 60 min PO, 60 to 90 min |
Cycle 1 day 8 and beyond |
| H2 receptor antagonist | Famotidine 20 mg IV | 15 to 30 min | Any cycle |
| Antiemetics | Ondansetron 8 mg PO or 16 mg IV | 15 to 30 min | Any cycle |
PO, oral; IV, intravenous. a beginning with cycle 1 day 8, optional pre-dose steroids were administered if clinically indicated for patients who experienced an infusion-related reaction on cycle 1 day 1 or cycle 1 day 2. b Required at all doses.