Figure 3.

Schematic representation of transcription-related pathways regulated by p300. (A) The p300 gene recognises phosphorylated AR in prostate cancer and promotes AR acetylation in K609, thereby promoting transcription. (B) A485, an inhibitor of p300, can reduce the level of transcription of highly expressed genes by reducing the level of H3K27ac in particular genes (such as ER). (C) In esophageal adenocarcinoma, p300 acetylates K188 and K189 of Maml1, and recruits NACK to the ternary complex of Notch1, resulting in the initiation of transcription. (D) p300 can catalyse the lactate of YTHDF2 promoter in ocular melanoma cells and then regulate the transcription process. (Remarks: The grey arrow is the related process in which p300 inhibitors participate in regulation, and the dotted line is the process in which modification types are removed).