Table 2.

As the therapeutic target of DIC, the regulatory role of miRNA in DIC.

miRNA	Source	Sample	Intervention Drug	Target/Pathway	Function	References
miR-1	Cell strain	H9c2 cell	Paeoniflorin	Bcl-2	Oxidative stress, apoptosis	[164]
miR-17-5p	Rat	Cardiomyocyte	Antagonist	PTEN	Oxidative stress, apoptosis	[176]
miR-21	Mice	Heart tissue	Exosome-mediated miR-21	N/A	Apoptosis	[201]
miR-22	Mice	Cardiomyocyte	Antagonist	SIRT1	Oxidative stress, apoptosis	[179]
miR-23a	NRVMs	Cardiomyocyte	Antagonist	PGC-1α/p-Drp1	Protect mitochondria	[196]
miR-24	Rat	Cardiomyocyte	LGZG	JP-2	Protect mitochondria	[195]
miR-25	Cell strain	H9c2 cell	Antagonist	Bax, Bcl-2, PTEN	Oxidative stress, apoptosis	[180]
miR-34a	Rat	Cardiomyocyte	Antagonist	Bcl-2, SIRT1	Oxidative stress, apoptosis	[181]
	Rat	CPCs	Antagonist	Bcl-2, SIRT1, p53	Apoptosis	[182]
	Cell strain	H2c9 cell	MSCs	p53, p16, SIRT1	Apoptosis	[186]
miR-96	Rat	Cardiomyocyte	Antagonist	NF-κB	Apoptosis	[202]
miR-128-3p	Mice	Cardiomyocyte	Antagonist	PPAR-γ, Bax	Oxidative stress, apoptosis	[203]
miR-133	Cell strain	H2c9 cell	Tanshinone IIA	caspase-9	Apoptosis	[167]
miR-143	mice	Cardiomyocyte	Antagonist	BCL-2, BAX, caspase-3	Oxidative stress, apoptosis	[191]
	Cell strain	H2c9 cell	Antagonist	BCL-2, BAX, caspase-3, PKB, AKT	Oxidative stress	[191]
miR-140-5p	Cell strain	H2c9 cell	Dioscin	Nrf2, Sirt2	Oxidative stress, apoptosis	[173]
miR-152-3p	Rat	Cardiomyocyte	DNMT1	ETS1, RhoH	DNA methylation
miR-199	Mice	Cardiomyocyte	Antagonist	Bax, Bcl-2, TAF9b	Oxidative, autophagy	[204]
miR-200a	Cell strain	H2c9 cell	Antagonist	Keap1, Nrf2	Oxidative stress, apoptosis	[188]
miR-200a-3p	Rat	Cardiomyocyte	Antagonist	SIRT1/NF-κB, PEG3	Apoptosis	[187]
miR-375	Rat	Cardiomyocyte	Antagonist	Bax, Bcl-2	Oxidative stress, apoptosis	[192]
	Cell strain	H2c9 cell, AMCs	Antagonist	PDK1, AKT	Oxidative stress, apoptosis	[192]
miR-208a	Mice	Heart tissue	Antagonist	GATA4, Bcl-2	Oxidative stress, apoptosis	[184]
miR-425	Mice	plasma	Irigenin	Bcl-2, Bax, Caspase-3	Oxidative stress, apoptosis	[169]
	Cell strain	HL-1	Irigenin	Bcl-2, Bax, Caspase-3, PARP	Oxidative stress, apoptosis	[169]
miR-495-3p	Cell strain	H2c9 cell	Irigenin	PKB/AKT	Oxidative stress, apoptosis	[205]
miR-875-3p	Cell strain	H2c9 cell	lncRNA HOXB-AS3	N/A	Apoptosis	[206]
miR-1303	Cell strain	A16	Kinetochore-associated protein 3	TLR4	Apoptosis	[207]