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. 2023 Mar 8;15(6):1670. doi: 10.3390/cancers15061670

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Preserved Lgr5+ GFP+ stem cells in the intestine of LR-IFN-β-gavaged irradiated mice. Increased Lgr5+ GFP+ stem cells in the intestine of LR-IFN-β irradiated (12 Gy TBI) mice. (A) Cross-sections of ileum from each group (×200). (B) Quantitation of the percentage of positive cells out of 100 cross-sections counted for each group of n = 5 for villi position. (C) Quantitation of number of crypts/sections scored. (D) Quantitation of number of GFP+ cells containing crypts scored. The * represents significant difference between the treatment groups and 0 Gy. The # represents significant difference between the treatment groups and the 12 Gy + LR-IFN-β group.

Preserved Lgr5+ GFP+ stem cells in the intestine of LR-IFN-β-gavaged irradiated mice. Increased Lgr5+ GFP+ stem cells in the intestine of LR-IFN-β irradiated (12 Gy TBI) mice. (A) Cross-sections of ileum from each group (×200). (B) Quantitation of the percentage of positive cells out of 100 cross-sections counted for each group of n = 5 for villi position. (C) Quantitation of number of crypts/sections scored. (D) Quantitation of number of GFP+ cells containing crypts scored. The * represents significant difference between the treatment groups and 0 Gy. The # represents significant difference between the treatment groups and the 12 Gy + LR-IFN-β group.