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. 2023 Mar 12;15(6):1728. doi: 10.3390/cancers15061728

Figure 2.

Figure 2

Gene mutation prevalence, loss of heterozygosity and copy number alterations in primary tumor, extracerebral metastases and brain metastases. Panel (A) shows a heatmap plot for the prevalence of gene mutations according to the tumor site (primary tumor, extracerebral metastases and brain metastases). Panel (B) shows the increased prevalence of gene mutations in brain metastases for 8 genes: TP53, BRCA2, PTEN, ESR1, ERBB2, NRAS, NOTCH1, EGFR. p-values reported here corresponded to those of Table 1 and of the pairwise comparison of gene mutation prevalence between brain metastases and extracerebral metastases. Panel (C) shows the loss of heterozygosity and material gain identified in breast cancer brain metastases.