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. 2023 Mar 8;15(6):1664. doi: 10.3390/cancers15061664

Table 2.

MCL variants.

  • Primary MCL (developing de novo)

  • Secondary MCL (developing from a prior MC neoplasm)

  • Acute MCL (with organ damage, so-called C-findings and aggressive course)

  • Chronic MCL (without C-findings and a more stable course, but evolving to acute MCL over a variable length of time)

  • MCL (alone)

  • MCL with an associated hematological neoplasm (MCL-AHN) 1

  • MCL leukemic variant (with at least 10% atypical immature circulating MCs) 2

  • MCL aleukemic variant (with less than 10% atypical immature circulating MCs) 2

Legend: 1 MCL-ANH is renamed MCL with an associated myeloid neoplasm (MCL-AMN) in the 2022 ICC, as MCL is mainly associated with neoplasms of myeloid origin often clonally related to MCL; 2 in the 2022 ICC, it is recommended to report any circulating atypical immature MCs because of the negative prognostic significance.