Table 2.

mTOR pathway alterations in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).

Authors	Site	mTOR	Other Findings
Tran et al. [177]	Metastatic (nodal and liver) pancreatic	↑	↓SSTR
Borga et al. [32]	Metastatic (nodal and liver) ileal	↑ (++ liver)	↑SSTR5 (liver) intra-spot SSTR2A/SSTR5 expression heterogeneity
Karphatakis et al. [43]	Metastatic (liver) small intestine	↑	-
Gilbert et al. [178]	NENs (including small intestine)	↑primary ↓metastases	-

Table 2 summarises the studies that have investigated the pattern of mTOR expression in primary and metastatic GEP-NENs. Two studies have also investigated the SSTR expression in both sites. Abbreviations; mTOR: mammalian target of rapamycin; SSTR: somatostatin receptor.