Table 2.
Age- and sex-specific mean volumes of regions of interest.
2–3 y | 3–4 y | 4–5 y | 5–6 y | 6–7 y | 7–8 y | 8–9 y | 9–10 y | 10–11 y | 11–12 y | 12–13 y | 13–14 y | 14–15 y | 15–16 y | 16–17 y | 17–18 y | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | Mean | STD | |||
TBV | Female | 955 | 70 | 1042 | 84 | 1080 | 86 | 1116 | 90 | 1126 | 88 | 1115 | 80 | 1113 | 87 | 1157 | 159 | 1182 | 74 | 1188 | 90 | 1165 | 73 | 1173 | 79 | 1163 | 102 | 1147 | 98 | 1145 | 118 | 1140 | 110 | |
Male | 1004 | 83 | 1144 | 118 | 1172 | 139 | 1211 | 110 | 1212 | 106 | 1235 | 92 | 1296 | 123 | 1264 | 104 | 1271 | 88 | 1262 | 94 | 1260 | 104 | 1271 | 103 | 1310 | 159 | 1308 | 143 | 1243 | 81 | 1263 | 96 | ||
HIPPO (×10−3) | Female | Left | 2.59 | 0.43 | 2.82 | 0.31 | 2.97 | 0.24 | 3.07 | 0.25 | 3.06 | 0.27 | 3.12 | 0.22 | 3.18 | 0.30 | 3.31 | 0.45 | 3.32 | 0.29 | 3.37 | 0.34 | 3.34 | 0.29 | 3.38 | 0.27 | 3.38 | 0.30 | 3.35 | 0.30 | 3.49 | 0.32 | 3.36 | 0.39 |
Right | 2.59 | 0.18 | 2.94 | 0.32 | 3.03 | 0.27 | 3.16 | 0.29 | 3.15 | 0.29 | 3.21 | 0.24 | 3.22 | 0.29 | 3.36 | 0.44 | 3.36 | 0.23 | 3.42 | 0.38 | 3.40 | 0.28 | 3.42 | 0.29 | 3.43 | 0.32 | 3.41 | 0.32 | 3.52 | 0.33 | 3.43 | 0.37 | ||
Male | Left | 2.67 | 0.29 | 3.02 | 0.34 | 3.14 | 0.31 | 3.25 | 0.27 | 3.22 | 0.33 | 3.46 | 0.49 | 3.44 | 0.47 | 3.66 | 0.31 | 3.57 | 0.40 | 3.38 | 0.33 | 3.51 | 0.38 | 3.58 | 0.31 | 3.77 | 0.47 | 3.60 | 0.40 | 3.68 | 0.45 | 3.64 | 0.38 | |
Right | 2.81 | 0.26 | 3.10 | 0.38 | 3.19 | 0.31 | 3.37 | 0.29 | 3.27 | 0.31 | 3.48 | 0.32 | 3.54 | 0.44 | 3.76 | 0.34 | 3.63 | 0.43 | 3.45 | 0.30 | 3.64 | 0.46 | 3.68 | 0.34 | 3.82 | 0.49 | 3.69 | 0.36 | 3.83 | 0.45 | 3.76 | 0.37 | ||
P-HIPPO (×10−3) | Female | Left | 1.93 | 0.26 | 2.20 | 0.29 | 2.21 | 0.27 | 2.22 | 0.30 | 2.37 | 0.32 | 2.40 | 0.40 | 2.35 | 0.35 | 2.29 | 0.40 | 2.48 | 0.42 | 2.41 | 0.31 | 2.31 | 0.33 | 2.38 | 0.31 | 2.34 | 0.37 | 2.34 | 0.33 | 2.37 | 0.30 | 2.33 | 0.29 |
Right | 1.79 | 0.24 | 2.02 | 0.26 | 2.08 | 0.20 | 2.07 | 0.23 | 2.12 | 0.35 | 2.21 | 0.23 | 2.14 | 0.39 | 2.06 | 0.34 | 2.23 | 0.36 | 2.23 | 0.28 | 2.20 | 0.31 | 2.22 | 0.27 | 2.14 | 0.24 | 2.14 | 0.21 | 2.19 | 0.28 | 2.06 | 0.20 | ||
Male | Left | 2.04 | 0.16 | 2.16 | 0.31 | 2.20 | 0.25 | 2.35 | 0.37 | 2.31 | 0.34 | 2.45 | 0.27 | 2.35 | 0.37 | 2.44 | 0.38 | 2.43 | 0.42 | 2.33 | 0.37 | 2.41 | 0.38 | 2.49 | 0.27 | 2.49 | 0.36 | 2.48 | 0.29 | 2.46 | 0.43 | 2.33 | 0.27 | |
Right | 1.71 | 0.23 | 2.09 | 0.33 | 2.01 | 0.30 | 2.14 | 0.30 | 2.07 | 0.30 | 2.16 | 0.34 | 2.20 | 0.28 | 2.36 | 0.37 | 2.19 | 0.33 | 2.17 | 0.23 | 2.27 | 0.35 | 2.27 | 0.24 | 2.38 | 0.39 | 2.35 | 0.29 | 2.20 | 0.45 | 2.19 | 0.32 | ||
AMYG (×10−3) | Female | Left | 1.37 | 0.23 | 1.40 | 0.11 | 1.50 | 0.12 | 1.52 | 0.13 | 1.56 | 0.14 | 1.60 | 0.09 | 1.57 | 0.13 | 1.66 | 0.23 | 1.65 | 0.13 | 1.70 | 0.17 | 1.68 | 0.13 | 1.69 | 0.16 | 1.69 | 0.12 | 1.69 | 0.16 | 1.75 | 0.17 | 1.65 | 0.17 |
Right | 1.34 | 0.10 | 1.44 | 0.11 | 1.52 | 0.14 | 1.57 | 0.10 | 1.58 | 0.12 | 1.67 | 0.13 | 1.62 | 0.14 | 1.71 | 0.24 | 1.72 | 0.13 | 1.77 | 0.18 | 1.72 | 0.14 | 1.75 | 0.15 | 1.75 | 0.14 | 1.75 | 0.17 | 1.84 | 0.18 | 1.72 | 0.18 | ||
Male | Left | 1.40 | 0.16 | 1.55 | 0.17 | 1.63 | 0.20 | 1.65 | 0.15 | 1.65 | 0.14 | 1.79 | 0.25 | 1.80 | 0.24 | 1.79 | 0.13 | 1.79 | 0.17 | 1.78 | 0.16 | 1.84 | 0.18 | 1.82 | 0.17 | 1.90 | 0.27 | 1.93 | 0.25 | 1.88 | 0.21 | 1.87 | 0.21 | |
Right | 1.43 | 0.16 | 1.62 | 0.19 | 1.65 | 0.22 | 1.73 | 0.16 | 1.69 | 0.15 | 1.78 | 0.18 | 1.86 | 0.28 | 1.87 | 0.16 | 1.85 | 0.20 | 1.83 | 0.18 | 1.90 | 0.21 | 1.90 | 0.18 | 1.95 | 0.24 | 1.97 | 0.22 | 1.97 | 0.20 | 1.95 | 0.22 | ||
HYPOTH (×10−3) | Female | Left | 0.30 | 0.02 | 0.34 | 0.04 | 0.34 | 0.04 | 0.33 | 0.06 | 0.32 | 0.08 | 0.35 | 0.04 | 0.32 | 0.07 | 0.37 | 0.03 | 0.37 | 0.05 | 0.39 | 0.04 | 0.39 | 0.04 | 0.40 | 0.03 | 0.41 | 0.04 | 0.41 | 0.03 | 0.41 | 0.03 | 0.41 | 0.04 |
Right | 0.30 | 0.02 | 0.33 | 0.04 | 0.33 | 0.04 | 0.32 | 0.07 | 0.32 | 0.07 | 0.36 | 0.04 | 0.33 | 0.06 | 0.37 | 0.04 | 0.37 | 0.04 | 0.36 | 0.05 | 0.39 | 0.04 | 0.39 | 0.05 | 0.40 | 0.05 | 0.40 | 0.03 | 0.40 | 0.03 | 0.40 | 0.04 | ||
Male | Left | 0.32 | 0.05 | 0.37 | 0.04 | 0.35 | 0.05 | 0.37 | 0.04 | 0.36 | 0.07 | 0.35 | 0.08 | 0.38 | 0.07 | 0.35 | 0.05 | 0.40 | 0.04 | 0.41 | 0.04 | 0.43 | 0.03 | 0.44 | 0.04 | 0.44 | 0.05 | 0.44 | 0.03 | 0.42 | 0.04 | 0.46 | 0.04 | |
Right | 0.30 | 0.04 | 0.35 | 0.04 | 0.33 | 0.05 | 0.36 | 0.04 | 0.34 | 0.08 | 0.36 | 0.07 | 0.36 | 0.09 | 0.35 | 0.07 | 0.39 | 0.05 | 0.40 | 0.05 | 0.41 | 0.03 | 0.42 | 0.06 | 0.43 | 0.05 | 0.42 | 0.04 | 0.40 | 0.06 | 0.44 | 0.03 | ||
CING (×10−3) | Female | Left | 11.69 | 1.32 | 13.12 | 1.31 | 13.73 | 1.16 | 14.08 | 1.23 | 14.16 | 1.33 | 13.89 | 1.52 | 14.07 | 1.89 | 14.12 | 2.95 | 14.20 | 1.65 | 14.44 | 1.82 | 14.02 | 1.42 | 14.21 | 1.48 | 13.52 | 1.57 | 13.25 | 1.81 | 13.83 | 1.65 | 12.96 | 1.55 |
Right | 10.42 | 1.03 | 10.97 | 1.80 | 12.33 | 1.52 | 12.33 | 1.51 | 11.83 | 1.33 | 12.14 | 1.31 | 11.64 | 1.72 | 11.86 | 2.38 | 12.15 | 1.17 | 12.05 | 1.62 | 12.05 | 1.43 | 11.86 | 1.33 | 11.34 | 1.19 | 11.21 | 1.51 | 11.58 | 1.38 | 10.71 | 1.32 | ||
Male | Left | 12.93 | 1.57 | 14.74 | 1.38 | 14.48 | 1.98 | 15.40 | 1.79 | 15.23 | 1.72 | 15.33 | 1.90 | 15.75 | 2.18 | 15.02 | 1.28 | 15.58 | 1.85 | 14.88 | 1.46 | 14.95 | 2.24 | 14.77 | 1.51 | 15.95 | 2.48 | 15.67 | 1.88 | 14.16 | 1.42 | 14.41 | 2.19 | |
Right | 10.78 | 1.28 | 12.42 | 1.38 | 12.15 | 1.90 | 12.81 | 1.83 | 12.70 | 1.70 | 12.78 | 1.28 | 13.24 | 2.04 | 12.87 | 1.50 | 12.78 | 1.42 | 12.86 | 1.24 | 12.44 | 1.84 | 12.58 | 1.80 | 13.12 | 1.78 | 12.85 | 1.95 | 11.32 | 1.24 | 12.36 | 1.45 | ||
ENTO (×10−3) | Female | Left | 1.17 | 0.25 | 1.53 | 0.47 | 1.56 | 0.38 | 1.56 | 0.45 | 1.55 | 0.22 | 1.57 | 0.33 | 1.49 | 0.29 | 1.58 | 0.34 | 1.77 | 0.40 | 1.63 | 0.23 | 1.65 | 0.35 | 1.69 | 0.49 | 1.67 | 0.48 | 1.74 | 0.48 | 1.78 | 0.41 | 1.75 | 0.31 |
Right | 1.19 | 0.14 | 1.47 | 0.36 | 1.56 | 0.39 | 1.46 | 0.35 | 1.46 | 0.24 | 1.54 | 0.37 | 1.46 | 0.26 | 1.46 | 0.24 | 1.62 | 0.39 | 1.56 | 0.45 | 1.52 | 0.23 | 1.64 | 0.46 | 1.59 | 0.33 | 1.54 | 0.30 | 1.55 | 0.24 | 1.61 | 0.31 | ||
Male | Left | 1.41 | 0.41 | 1.65 | 0.47 | 1.51 | 0.31 | 1.71 | 0.41 | 1.71 | 0.31 | 1.85 | 0.44 | 1.78 | 0.34 | 2.00 | 0.36 | 1.93 | 0.60 | 1.84 | 0.43 | 1.79 | 0.48 | 1.95 | 0.68 | 1.92 | 0.31 | 1.82 | 0.27 | 1.78 | 0.37 | 1.81 | 0.32 | |
Right | 1.39 | 0.26 | 1.44 | 0.33 | 1.53 | 0.37 | 1.69 | 0.46 | 1.58 | 0.33 | 1.59 | 0.40 | 1.67 | 0.37 | 2.00 | 0.58 | 1.72 | 0.46 | 1.67 | 0.36 | 1.66 | 0.45 | 1.64 | 0.37 | 1.79 | 0.26 | 1.69 | 0.31 | 1.70 | 0.32 | 1.74 | 0.59 | ||
AV-THAL (×10−3) | Female | Left | 0.13 | 0.01 | 0.13 | 0.02 | 0.15 | 0.02 | 0.14 | 0.02 | 0.13 | 0.01 | 0.15 | 0.02 | 0.14 | 0.02 | 0.14 | 0.04 | 0.14 | 0.02 | 0.15 | 0.02 | 0.15 | 0.02 | 0.14 | 0.02 | 0.15 | 0.02 | 0.14 | 0.02 | 0.14 | 0.02 | 0.14 | 0.02 |
Right | 0.14 | 0.02 | 0.14 | 0.02 | 0.15 | 0.02 | 0.15 | 0.02 | 0.15 | 0.02 | 0.16 | 0.02 | 0.15 | 0.02 | 0.15 | 0.04 | 0.15 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.15 | 0.02 | 0.16 | 0.03 | 0.15 | 0.02 | 0.15 | 0.02 | 0.15 | 0.02 | ||
Male | Left | 0.12 | 0.02 | 0.15 | 0.02 | 0.15 | 0.03 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.15 | 0.02 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.03 | 0.15 | 0.02 | 0.16 | 0.03 | |
Right | 0.14 | 0.02 | 0.16 | 0.02 | 0.16 | 0.03 | 0.17 | 0.02 | 0.17 | 0.03 | 0.16 | 0.02 | 0.17 | 0.02 | 0.17 | 0.01 | 0.17 | 0.02 | 0.17 | 0.02 | 0.16 | 0.02 | 0.17 | 0.02 | 0.17 | 0.03 | 0.17 | 0.02 | 0.16 | 0.02 | 0.16 | 0.03 | ||
THAL (×10−3) | Female | Left | 5.92 | 0.40 | 6.32 | 0.44 | 6.67 | 0.43 | 6.82 | 0.48 | 6.79 | 0.50 | 7.00 | 0.45 | 6.79 | 0.67 | 7.20 | 1.26 | 7.16 | 0.52 | 7.36 | 0.63 | 7.19 | 0.61 | 7.36 | 0.66 | 7.25 | 0.75 | 7.14 | 0.71 | 7.38 | 0.73 | 7.16 | 0.71 |
Right | 6.09 | 0.39 | 6.38 | 0.43 | 6.70 | 0.38 | 6.80 | 0.57 | 6.85 | 0.54 | 6.93 | 0.52 | 6.75 | 0.69 | 7.17 | 1.18 | 7.04 | 0.42 | 7.32 | 0.68 | 7.10 | 0.60 | 7.24 | 0.53 | 7.16 | 0.68 | 7.13 | 0.62 | 7.27 | 0.72 | 6.87 | 0.73 | ||
Male | Left | 6.12 | 0.61 | 7.10 | 0.72 | 7.03 | 0.79 | 7.43 | 0.65 | 7.41 | 0.67 | 7.36 | 0.47 | 7.70 | 0.75 | 7.73 | 0.62 | 7.82 | 0.62 | 7.62 | 0.69 | 7.78 | 0.58 | 7.91 | 0.69 | 8.13 | 0.90 | 8.16 | 0.96 | 7.71 | 0.67 | 7.97 | 0.83 | |
Right | 6.30 | 0.62 | 6.99 | 0.56 | 6.99 | 0.73 | 7.37 | 0.70 | 7.29 | 0.70 | 7.25 | 0.63 | 7.60 | 0.75 | 7.62 | 0.41 | 7.70 | 0.62 | 7.48 | 0.58 | 7.64 | 0.59 | 7.78 | 0.63 | 7.77 | 0.80 | 7.86 | 0.88 | 7.57 | 0.53 | 7.94 | 0.84 |
Legend: Results are given in mean volume in milliliters and standard deviation (STD). Years (y), total brain volume (TBV), hippocampus (HIPPO), parahippocampal gyrus (P-HIPPO), amgydala (AMYG), hypothalamus (HYPOTH), parahippocampal gyrus (P-HIPPO), amygdala (AMYG), hypothalamus (HYPOTH), cingulate gyrus (CING), antero-ventral nucleus of thalamus (AV-THAL), whole thalamus (THAL). The maximum volumes are in bold and underlined.