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. 2023 Mar 8;12(6):832. doi: 10.3390/cells12060832

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Representative flow cytometry analysis of EVs derived from plasma of NR (#146) and CR (#174) patients, at both T0 and T1. Areas under blue and pink lines indicate EVs reacting with PD-L1 (upper panels) or B7-H3 (bottom panels) at T0 and T1, respectively. Areas under the grey lines indicate the interactions of vesicles with corresponding non-reactive immunoglobulin of the same isotype. (b,c) Histograms representing the percentage of PD-L1- (b) or B7-H3-positive EVs (c) derived from NR and CR/PR patients, at both T0 and T1. *: p < 0.05, **: p < 0.01, ****: p < 0.0001 (one-way ANOVA). (d) Western blot analysis of Flotillin-1, PD-L1 and B7-H3 on EVs derived from plasma of NR (#146) and CR (#174) patients, at both T0 and T1.