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. 2023 Mar 15;12(6):900. doi: 10.3390/cells12060900

Figure 1.

Figure 1

Ack family kinases. Linear representation of Ack family members. The residue numbers below each domain depict the boundaries of the domains retrieved from the UniProtKB [10]. SAM, sterile alpha motif; NES, nuclear export signal; CRIB, Cdc42, and Rac-interactive binding (CRIB) domain; CB, clathrin-binding motif; proline-rich region; MHR, Mig6 homology region; UBA, ubiquitin-associated domain. The sequence identity between each member and human Ack1 (or TNK1) is indicated to the left of the linear diagram as percentage identity. UniProtKB IDs used to depict the domain arrangements and to determine percent sequence identity are human Ack1, Q07912; bovine Ack2, Q17R13; mouse Ack1/Pyk1, O54967; fruit fly DACK, Q9VZI2; fruit fly Ack-like/DPR2/PR2, Q9I7F7; worm Ark-1, G5EBZ8; worm sid-3, Q10925; human TNK1, Q13470; and mouse TNK1/Kos1, Q99ML2.