Figure 10.

Differential methylation status of checkpoint signaling genes. Differential methylation in BRAF mutant patients is shown in (A), and the differential methylation of BRAF wild-type patients is shown in (B). Gene probes are arranged on the x-axis by methylation level, and the mean of beta value is shown on the y-axis. For many genes, there were multiple probes on the chip. Gene symbols for all gene probes could not be shown on the x-axis. Multiple probes were hypermethylated in both groups. However, the overall magnitude was slightly higher in wild type.