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CAF factors influence pro-tumor processes. CAF-derived molecules TGF-β, HGF, LIF, CXCL1, and FGF1 impact ECM remodeling. Factors SDF-1, MCP1, IL-8, Il-8, and TGF-β modulate the immune system. TGF-β, IL-6, HGF, MCP1, SDF-1, CXCL1, and FGF1 impact tumor growth and metastasis.
