Table 1.

Signaling molecules and growth factors secreted by CAFs into the TME.

Factor	Receptor	Reference
TGF-β1 and TGF-β2	TGF-βR type I and II	[61,62,63,64,65,66,67]
IL-6	IL-6R	[68,69]
IL-8	CXCR1/2	[70,71]
MCP1 (CCL2)	CCR-2	[72,73,74]
HGF (SF)	c-Met	[75,76]
LIF	LIFR	[77,78]
SDF-1 (CXCL12)	CXCR4	[8,79]
CXCL1	CXCR2	[48,80,81]
FGF1, FGF2, and FGF9	FGFR, FGFR2, and FGFR9	[82,83]
CCL-5	CCR1, CCR3, and CCR5	[84]
IL-11	IL-11R	[84]