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. 2023 Mar 8;12(6):837. doi: 10.3390/cells12060837

Figure 3.

Figure 3

Experiment 1: Sub-Chronic Vortioxetine Intervention in Dyskinetic Rats. Rats (N = 26) were treated with vortioxetine (VTX; 3, 10 mg/kg, s.c.) or vehicle (VEH) 5 min prior to administration of L-DOPA (LD; 6 mg/kg, s.c.) or VEH for 14 consecutive days following a 2 week daily L-DOPA only regimen in a between-subjects design (n = 6 VEH-VEH, n = 6 VEH-LD; n = 7 VTX(3)-LD; n = 7 VTX(10)-LD). Axial, limb, and orolingual (ALO) abnormal involuntary movements were observed over a 3 h time course every 10 min following the L-DOPA injection. To determine effects over the 2-week testing period, (A) weekly ALO AIMs sums are shown and were expressed as median and mean absolute deviation (M.A.D.). To examine the time-course of effects on the final day of testing (B), individual timepoints are shown for each group’s ALO AIMs. Significant differences in ALO AIMs between treatments on each day (A) and across time course (B) were determined using non-parametric Kruskal–Wallis ANOVAs with Mann–Whitney U’s post hoc tests. * p < 0.05 VEH-VEH vs. VEH-LD; + p < 0.05 VEH-VEH vs. VTX(3)-LD; # p < 0.05 VEH-VEH vs. VTX(10)-LD; ^ p < 0.05 VEH-LD vs. VTX(3); @ p < 0.05 VEH-LD vs. VTX(10)-LD.