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Reduced apoptosis in HL-1 cardiomyocytes treated with CM from ELSM-treated C-MSC is dependent on nSMase2. (A–D) Percentage of TUNEL+ cardiomyocytes treated with CM from si-NT transfected C-MSC without ELSM, si-NT transfected C-MSC with ELSM, si-nSMase2 transfected C-MSC without ELSM, and si-nSMase2 transfected C-MSC with ELSM; (E) statistical analysis of the percentage of TUNEL+ cardiomyocytes in the 4 groups (ns not significant; * p < 0.05, ** p < 0.01, n = 3).
