Figure 2.

Temporal changes in metabolites and inflammatory cytokines in 28-d septic shock survivors and non-survivors. The most perturbed analytes across time and 28-d mortality status measured using three analytical platforms: A, acylcarnitines measured by liquid chromatography-mass spectrometry; B, metabolites measured by nuclear magnetic resonance; and C, Proteins measured by immunoassays. Analyte concentrations at each time point are visualized with the median ± 25th and 75th percentiles, with differences between mortality groups assessed by the Mann-Whitney U test. Analytes presented here were chosen according to the rank-ordered overall p value from linear mixed modeling as described in the Materials and Methods section. IL = interleukin.