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. 2023 Mar 27;5(4):e0881. doi: 10.1097/CCE.0000000000000881

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Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 3. — Repeated-measure correlations between protein and metabolite analytes. The Rmcorr R package was used to determine the repeated-measure correlation coefficient between proteins and metabolites measured across three time points. The ggcorrplot R package was used to visualize the results. Positive correlations are indicated in red, while negative correlations are shown in blue, and only significant (p < 0.05) correlation pairs are included. ANG2 = angiopoietin-2; TNFα = tumor necrosis factor-alpha; IL = interleukin.