Table 3.
Association of assessed IHC markers with survival parameters in the melanoma group.
| PFS | OS | ||||||
|---|---|---|---|---|---|---|---|
| Characteristic | N | HR | Median Survival | p-Value | HR | Median Survival | p-Value |
| CD3 IEL | 0.202 | 0.122 | |||||
| Negative | 13 | — | — | — | — | ||
| Positive | 16 | 1.87 | 8.8 | 2.27 | 25 | ||
| CD3 stromal | 0.667 | 0.834 | |||||
| Negative | 6 | — | 9.5 | — | 47 | ||
| Positive | 22 | 0.78 | 15 | 1.15 | 26 | ||
| CD8 IEL | 0.484 | 0.093 | |||||
| Negative | 17 | — | 11 | — | — | ||
| Positive | 12 | 1.38 | 10 | 2.31 | 22 | ||
| CD8 stromal | 0.811 | 0.539 | |||||
| Negative | 7 | — | 11 | — | 13 | ||
| Positive | 22 | 1.14 | 9.5 | 0.70 | 27 | ||
| CD20 | 0.966 | 0.417 | |||||
| Negative | 26 | — | 9.5 | — | 31 | ||
| Positive | 4 | 0.97 | 13 | 1.68 | 25 | ||
| CD68 | 0.034 | 0.968 | |||||
| Negative | 26 | — | 15 | — | 27 | ||
| Positive | 4 | 3.21 | 4.1 | 1.03 | 36 | ||
| FoxP3 | 0.048 | 0.852 | |||||
| Negative | 25 | — | 17 | — | 27 | ||
| Positive | 4 | 3.04 | 4.5 | 1.15 | 33 | ||
| IDO1 | 0.519 | 0.180 | |||||
| Negative | 23 | — | 8.0 | — | 26 | ||
| Positive | 7 | 0.70 | 15 | 0.38 | — | ||
| LAG-3 | 0.606 | 0.770 | |||||
| Negative | 23 | — | 11 | — | 31 | ||
| Positive | 7 | 0.75 | 15 | 1.18 | 25 | ||
| TGFβ IC | 0.384 | 0.366 | |||||
| Negative | 16 | — | 5.5 | — | 27 | ||
| Positive | 14 | 0.67 | 16 | 0.63 | — | ||
| TGFβ TC | 0.916 | 0.991 | |||||
| Negative | 26 | — | 11 | — | 27 | ||
| Positive | 4 | 0.92 | 33 | 1.01 | 39 | ||
| PD1 | 0.850 | 0.501 | |||||
| Negative | 22 | — | 11 | — | 31 | ||
| Positive | 8 | 1.10 | 10 | 1.44 | 25 | ||
| PD-L1 CPS | 0.052 | 0.794 | |||||
| <1 | 9 | — | 6.2 | — | 27 | ||
| ≥1 | 17 | 0.39 | 17 | 0.87 | 25 | ||
| PD-L1 CPS | 0.195 | 0.529 | |||||
| <10 | 19 | — | 8.0 | — | 26 | ||
| ≥10 | 7 | 0.45 | — | 0.67 | — | ||
| PD-L1 CPS | 0.407 | 0.240 | |||||
| <50 | 22 | — | 9.5 | — | 25 | ||
| ≥50 | 4 | 0.54 | 30 | 0.31 | — | ||
| PD-L1 TPS | 0.005 | 0.060 | |||||
| <1 | 18 | — | 5.5 | — | 20 | ||
| ≥1 | 9 | 0.20 | — | 0.32 | — | ||
| PD-L1 TPS | 0.268 | 0.467 | |||||
| <10 | 24 | — | 9.5 | — | 25 | ||
| ≥10 | 3 | 0.34 | — | 0.48 | — | ||
| PD-L1 TPS | 0.268 | 0.467 | |||||
| <50 | 24 | — | 9.5 | — | 25 | ||
| ≥50 | 3 | 0.34 | — | 0.48 | — | ||
| TMB high | 0.058 | 0.923 | |||||
| Negative | 9 | — | 4.4 | — | 27 | ||
| Positive | 17 | 0.41 | 15 | 0.95 | 26 | ||
Abbreviation: IEL, intraepithelial; IC, immune cell; TC tumor cell; CPS, combined positive score; TPS, tumor proportion score; TMB, tumor mutational burden. Median survival in months.