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Ligplot interactions of 4 leads with KRAS G12D mutant protein: The protein–ligand interactions of BI-2852 (reference), 5-Dehydroxyparatocarpin K (L1), Carpachromene (L2), Sanggenone H (L3), and Kuwanol C (L4) are represented as (A–E), respectively. The H-bonds and other hydrophobic and electrostatic interactions of these compounds are also shown.
