Table 4.

Intermolecular hydrogen-bond interactions of 4 leads.

Flavonoid Name	Interaction	Distance (Å)
BI-2852 (reference)	OG atom in Ser39 with N2 atom in BI-2852	3.11
	OD1 atom in Asp54 with N1 atom in BI-2852	2.84
5-Dehydroxyparatocarpin K (L1)	O atom in Leu6 with O4 atom in L1	2.79
	O atom in Asp54 with O4 atom in L1	3.00
Carpachromene (L2)	O atom in Leu6 with O4 atom in L2	2.78
	O atom in Asp54 with O4 atom in L2	2.97
Sanggenone H (L3)	O atom in Asp54 with O4 atom in L3	3.19
Kuwanol C (L4)	O atom in Leu6 with O5 atom in L4	2.70
	O atom in Asp54 with O5 atom in L4	2.48
	O atom in Tyr71 with O4 atom in L4	2.70