Table A8.
Candidate genes encoding targets/receptors of antipsychotics.
| Gene (OMIM * Number) | Chromosome Location ** | Genomic Coordinate ** | Protein *** |
|---|---|---|---|
| Dopaminergic system | |||
| DRD2 (126450) | 11q23.2 | chr11:113,409,605–113,475,691(GRCh38/hg38) | Dopaminergic receptor type D2 |
| DRD3 (126451) | 3q13.31 | chr3:114,127,580–114,199,407(GRCh38/hg38) | Dopaminergic receptor type D3 |
| DRD4 (126452) | 11p15.5 | chr11:637,269–640,706(GRCh38/hg38) | Dopaminergic receptor type D4 |
| Serotoninergic system | |||
| HTR2A (182135) | 13q14.2 | chr13:46,831,546–46,898,082(GRCh38/hg38) | Serotonergic 5-hydroxytryptamine receptor type 2A |
| HTR2C (312861) | Xq23 | chrX:114,584,078–114,910,061(GRCh38/hg38) | Serotonergic 5-hydroxytryptamine receptor type 2C |
| Glutamatergic system | |||
| GRIN2A (138253) | 16p13.2 | chr16:9,753,404–10,182,928(GRCh38/hg38) | Glutamate ionotropic receptor type 2A |
| GRIN2B (138252) | 12p13.1 | chr12:13,437,942–13,982,134(GRCh38/hg38) | Glutamate ionotropic receptor type 2B |
Note: * from the open database OMIM—Online Mendelian Inheritance in Man [78], ** from the open database GeneCards: The Human Gene Database [86], *** from the open database The Human Protein Atlas [81], DRD2—Dopamine Receptor D2, DRD3—Dopamine Receptor D3, DRD4—Dopamine Receptor D4, HTR2A—5-Hydroxytryptamine Receptor 2A, HTR2C—5-Hydroxytryptamine Receptor 2C, GRIN2A—Glutamate Ionotropic Receptor NMDA Type Subunit 2A, and GRIN2B—Glutamate Ionotropic Receptor NMDA Type Subunit 2B.