Table A9.
Candidate genes encoding key targets/enzymes of antipsychotics in the central nervous system.
| Gene (OMIM * Number) |
Chromosome Location ** | Genomic Coordinate ** | Protein *** |
|---|---|---|---|
| HSPG2 (142461) | 1p36.12 | chr1:21,822,244–21,937,310(GRCh38/hg38) | Perlecan |
| COMT (116790) | 22q11.21 | chr22:19,941,371–19,969,975(GRCh38/hg38) | Catechol-O-methyltransferase |
| NQO1 (125860) | 16q22.1 | chr16:69,706,996–69,726,668(GRCh38/hg38) | Quinone dehydrogenase nicotinamide adenine dinucleotide phosphate |
| RGS2 (600861) | 1q31.2 | chr1:192,809,039–192,812,275(GRCh38/hg38) | G protein signal transduction regulator 2 |
| GSTP1 (134660) | 11q13.2 | chr11:67,583,742–67,586,656(GRCh38/hg38) | Glutathione-S-transferase pi 1 |
| PPP1R1B (604399) | 17q12 | chr17:39,626,707–39,636,626(GRCh38/hg38) | Regulatory inhibitor of subunit 1B of protein phosphatase 1 |
| BDNF (113505) | 11p14.1 | chr11:27,654,893–27,722,058(GRCh38/hg38) | Brain-derived neurotrophic factor |
| MnSOD (147460) | 6q25.3 | chr6:159,669,069–159,762,281(GRCh38) | Manganese superoxide dismutase 2 |
Note: * from the open database OMIM—Online Mendelian Inheritance in Man [78], ** from the open database GeneCards: The Human Gene Database [86], *** from the open database The Human Protein Atlas [81], HSPG2—heparan Sulfate Proteoglycan 2, COMT—catechol-O-methyl transferase, NQO1—NAD(P)H quinone dehydrogenase 1, RGS2—regulator of G protein signaling 2, GSTP1—glutathione S-transferases P1, PPP1R1B—protein phosphatase 1 regulatory inhibitor subunit 1B, BDNF—brain-derived neurotrophic factor, and MnSOD—manganese superoxide dismutase.