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. 2023 Mar 4;14(3):651. doi: 10.3390/genes14030651

Figure 6.

Figure 6

EGFRvIII affected the migration, PMT of U87-EGFRvIII (+) cells, and TMZ sensitivity of U87-EGFRvIII (+) cells by regulating the NF-κB signaling pathway. (A) The cell migration was detected by Transwell assay in U87-EGFRvIII (+) cell pretreatment with NF-κB inhibitor (JSH-23) (scale bar: 100 μm). (B) The protein expression of CD44 and SOX2 was detected by Western blot in U87-EGFRvIII (+) cell pretreatment with NF-κB inhibitor (JSH-23). Representative data are determined from three independent experiments (n = 3 per group) vs. JSH-23 (−). * p < 0.05 by two-tailed Student’s t-test. (C) The half maximal inhibitory concentration of U87-EGFRvIII (+) cell pretreatment with NF-κB inhibitor (JSH-23) was detected by CCK8 assay.