Table 4.
Genotype and allele frequencies of DNMT3B rs2424913 gene polymorphism in Down syndrome individuals with atrial septal defects (ASDs) and other congenital heart defects (CHDs).
| ASD N (%) |
CHD N (%) |
χ2 | OR (95% Cl) | p-Value | |
|---|---|---|---|---|---|
| CC | 11 (24.4) | 30 (38.0) | 2.37 | 0.53 (0.23–1.20) | 0.126 |
| CT | 18 (40.0) | 35 (44.3) | 0.22 | 0.84 (0.40–1.76) | 0.642 |
| TT | 16 (35.6) | 14 (17.7) | 4.97 | 2.56 (1.11–5.93) | 0.028 |
| CC vs. CT + TT | Recessive | 2.37 | 0.53 (0.23–1.20) | 0.126 | |
| CC + CT vs. TT | Dominant | 4.97 | 0.39 (0.17–0.90) | 0.028 | |
| Allele | 5.69 | 0.53 (0.31–0.90) | 0.018 | ||
| C | 40 (44.4) | 95 (60.1) | |||
| T | 50 (55.6) | 63 (39.9) | |||
χ2: chi-square test; OR: odds ratio; Cl: confidence interval.