Table 2.

The dermal pharmacokinetic parameters obtained from the skin drug concentration–time profile of mangiferin in rodent skin.

Dermatokinetic Parameter	Conventional Gel	Microemulsion	Nano-Hydrogel
Cmax (μg/g of skin)	21.97 ± 1.98	60.45 ± 4.11	53.98 ± 5.07
Tmax (h)	0.75	2	2
${\mathrm{AUC}}_0^{\infty }$ (μg·mL−1·h)	41.55 ± 9.03	361.31 ± 36.13	328.46 ± 23.18
Kp (h−1)	1.91	5.01	4.67
K(h−1)	0.43	0.28	0.29
T1/2 (h−1)	1.61	2.48	2.38