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. 2023 Mar 10;14(3):688. doi: 10.3390/genes14030688

Figure 1.

Figure 1

Establishment of a mouse model of diet-induced obesity. (a) The appearance of HFD and LFD mice; (b) Average weekly body weight of HFD- and LFD-fed mice; (c) average daily food intake and energy intake per mouse. Average energy intake per mouse in the HFD or LFD group = different feed energy × average daily food intake per mouse. HFD: 21.92 kJ/g, LFD: 16.11 kJ/g; (d) serum concentration of FBG, TC, TG, HDL-C, and ALT between the HFD and LFD groups; (e) results of GTT and AUC of GTT (f) results of ITT and AUC of ITT; (g) liver morphology and HE staining of the liver (arrows point to fat vacuoles); the hepatic steatosis score of HFD mice = 1 (5~33%), ×200 microscope magnification (scale bar, 50 μm); (h) HE staining of adipose tissue (arrows show changes in the number and size of adipocytes), eWAT: epididymis white adipose tissue, iWAT: inguinal white adipose tissue, sWAT: subcutaneous adipose tissue, ×400 microscope magnification (scale bar, 50 μm). * p < 0.05, ** p < 0.01.