Table 2.
Defects of the Posterior Eye.
| Ocular Disease | Reference | Model | Zebrafish Features * | Human Features * |
|---|---|---|---|---|
| Age-related macular degeneration (AMD) | Noel et al., 2020 [49] | Mutation of rp1l1 | Photoreceptor degeneration | Photoreceptor diseases |
| Rastoin, Pagès, & Dufies, 2020 [50] | Extensive review | |||
| Xia et al., 2020 [51] | Knockdown of ube3d | Neovascular AMD | Oxidative damage in retinal pigment epithelium (hRPE) (in vitro) | |
| Cheng et al., 2021 [52] | Blue light-induced retinal damage | Retinal degeneration | Not described | |
| Noel, Allison, MacDonald, & Hocking, 2022 [53] | Extensive review | |||
| Diabetic retinopathy | Jung, Kim, Lee, & Kim, 2016 [54] | Glucose exposure | Neovascularization, dilation of hyaloid-retinal vessels | Diabetic retinopathy |
| Lee & Yang, 2021 [55] | ||||
| Singh et al., 2019 [56] | Neovascularization, dilation of hyaloid-retinal vessels, and microvascular alterations | |||
| Reichenbach et al., 2007 [57] | Extensive review | |||
| Li et al., 2019 [58] | Methylglyoxal exposure | Neovascularization, dilation of hyaloid-retinal vessels | Diabetic retinopathy | |
| Glaucoma | Skarie & Link, 2009 [59] | Knockdown of foxc1 | Disruption of vascular endothelial tissue | Glaucoma |
| Iglesias et al., 2014 [60] | Knockdown of six6b | Small eye phenotype | Not described | |
| Williams, Eason, Chawla, & Bohnsack, 2017 [61] | Manipulation of cyp1b1 | Regulation of ocular fissure closure | Mutation on cyp1b1 is related to primary infantile-onset glaucoma | |
| Giannaccini et al., 2018 [62] | Exposure to H2O2 | Oxidative stress-induced damage | Not described | |
| Cavodeassi & Wilson, 2019 [18] | Extensive review | |||
| Morales-Cámara et al., 2020 [63] | Knockout of guca1c | Retinal ganglion cell apoptosis | Not described | |
| Retinitis pigmentosa (RP) | Zelinka, Sotolongo-Lopez, & Fadool, 2018 [64] | Mutations of rh1–1 | Rod degeneration | Autosomal dominant retinitis pigmentosa |
| Ganzen et al., 2021 [65] | rho:NTR zebrafish line | Rod ablation | Not described | |
| Santhanam et al., 2020 [66] | Mutation of p23h | Rod degeneration | Not described | |
| Campochiaro & Mir, 2018 [67] | Extensive review | |||
| Crouzier et al., 2021 [68] | Mutation of pde6a | Photoreceptor degeneration | Retinitis pigmentosa | |
| Kawase et al., 2016 [69] | Ligh-induced retinopathy | Not described | ||
| Lu et al., 2019 [70] | Mutation of prom1 | Retinitis pigmentosa, macular degeneration, and cone–rod dystrophy | ||
| Noel et al., 2020 [49] | Mutation of rp1l1 | Photorecepetor disease | ||
| Schlegel, Ramkumar, von Lintig, & Neuhauss, 2021 [42] | Mutation of rlbp1 | |||
| Zhang et al., 2021 [71] | rho:NTR zebrafish line | Rod ablation | Not described | |
| Achromatopsia | Kennedy et al., 2007 [72] | No optokinetic response of mutant (nof) | Achromatopic blindness | Not described |
| Stearns, Evangelista, Fadool, & Brockerhoff, 2007 [73] | Mutation of pde6c | Blindness (degeneration of cone photoreceptors) | Achromatopsia | |
| Viringipurampeer et al., 2014 [74] | ||||
| Huang et al., 2018 [75] | Mutation of per2 | Reduced vision behavior | Not described | |
| Cone–rod dystrophy | Iribarne et al., 2017 [76] | Zebrafish Gold Rush mutant (aipl1 mutant) | Cone-specific degeneration | Leber congenital amaurosis 4 (LCA4) |
| Daly et al., 2017 [77] | Zebrafish dying on edge (dye) mutant | Defective visual behavior, altered retina morphology, photoreceptor degeneration | Visual impairment | |
| Schlegel et al., 2019 [78] | Knockout of cacna2d4b | Electroretinogram impaired response (defective phototransduction) | Retinal dysfunction (impaired cone vision) | |
| Nadolski et al., 2020 [43] | Mutation of gdf6a | Microphthalmia, photoreceptor degeneration | Not described | |
| Congenital stationary night blindness | Bahadori et al., 2006 [46] | Zebrafish fade out (fad) mutant | Retina structural defects, photoreceptor degeneration | Hermansky–Pudlak syndrome (HPS) |
| Jia et al., 2014 [44] | Zebrafish wait until dark (wud) mutant | Electroretinogram impaired response (defective phototransduction) | Congenital stationary night blindness type 2 (CSNB2) | |
| Leber’s congenital amaurosis (LCA) | Stiebel-Kalish et al., 2012 [48] | Knockdown of gucy2df | Shortening of cone and rod outer segments. | Leber congenital amaurosis-1 (LCA1). |
| Minegishi, Nakaya, & Tomarev, 2018 [47] | Mutation of cct2 | Microphthalmia | ||
| Bardet–Biedl syndrome (BBS) | Castro-Sánchez et al., 2019 [79] | Mutation of bbs | Microphthalmia | Ciliopathy |
| Song et al., 2020 [80] | Photoreceptor degeneration | |||
| Usher syndrome | Gopal et al., 2015 [81] | Knockout of clrn1 | Ciliopathy | Ciliopathy |
| Miles, Blair, Emili, & Tropepe, 2021 [82] | Mutation of pcdh15b | Loss of photoreceptor integrity | Blindness associated with Usher syndrome type 1 (USH1) | |
| Joubert syndrome | Song & Perkins, 2018 [83] | Mutation of arl13a | Slow progressive photoreceptor degeneration | Joubert syndrome phenotype |
| Liu, Cao, Yu, & Hu, 2020 [84] | Knockout of tmem216 | Photoreceptor degeneration | ||
| Rusterholz, Hofmann, & Bachmann-Gagescu, 2022 [85] | Extensive review | |||
| Meckel-Gruber syndrome | Lessieur et al., 2019 [86] | Zebrafish cep290fh297/fh297 mutant | Slow progressive photoreceptor degeneration | Meckel-Gruber syndrome phenotype |
| Hermansky-Pudlak syndrome | Bahadori et al., 2006 [46] | Zebrafish fade out (fad) mutant | Retina structural defects, photoreceptor degeneration | Hermansky–Pudlak syndrome (HPS) |
* Features specifically related to eye disorders.