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Interactions of Sp1 and lncRNAs. (A) Sp1 binds to the GC-rich promoter of a lncRNA to induce gene expression. (B) Silencing of Sp1 by miR-375 is reversed by competitive binding of a lncRNA to a miRNA. (C) Sp1 interacts with lncRNA XLOC013218 and forms an activation complex on the PIK3R2 gene promoter, whereas (D) MEG3 expression is inhibited by the EZH2/HDAC3/Sp1 complex.
