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Mechanisms of Sp downregulation [149,150,160,162,164]: ROS-inducers target Myc [149,150] whereas Metformin and WIN target kinases [189,190,191] to activate ZBTB (via miRNA downregulation), which displace Sp TFs from GC-rich sites. ZBTB genes induced via these pathways include ZBTB10, ZBTB34 and ZBTB4.
