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. 2023 Mar 9;24(6):5285. doi: 10.3390/ijms24065285

Figure 4.

Figure 4

PEL24-199 treatment increases PP2AC and GGA1 protein expression in APP/PS1 mice (A). Western blot analysis was performed in the cortex and hippocampus of water- and PEL24-199-treated APP/PS1 mice. (B–F) Histograms representing PP2AC, Cdk5, Gsk3-β, Fyn, and GGA1 protein levels in the cortex and hippocampus of PEL24-199-treated and untreated APP/PS1 mice. PP2AC expression was significantly increased both in the cortex and in the hippocampus, and GGA1 expression was elevated in the hippocampus. The analysis did not reveal any change in Cdk5, Gsk3-β, and Fyn expression (n = 4–8 per group). Significance at the Mann-Whitney statistical test is indicated by *: p < 0.05; **: p < 0.01 and ns as not significant.