. 2023 Mar 7;24(6):5088. doi: 10.3390/ijms24065088

Table 4.

Toxicity profiling of 3,4,5-trimethoxyaniline analogs containing a 3-cyanoquinoline scaffold similar to Bosutinib (33–43) ^a,b,c.


Name	R¹	R²	CM	CMI	ROS	GSH	NMI1	CC	NMI2	MMP	CHI
Bosutinib	-		1.00	1.00	1.00	1.00	1.00	0.91	1.00	1.00	0.94
Erlotinib	-		0.77	0.50	0.13	0.63	0.10	0.10	0.062	0.12	0.40
33	OMe	OMe	0.25	0.041	0.062	0.070	0.37	0.15	0.21	0.50	0.42
34	H	OMe	0.71	0.029	0.050	0.018	0.30	0.091	0.16	0.31	0.33
35	OMe	H	0.024	0.46	0.075	0.10	0.41	0.34	0.017	0.041	0.29
36	H	H	0.0021	0.57	0.072	0.042	0.13	0.35	0.047	0.019	0.23
37	Cl	H	0.19	0.013	0.28	0.010	0.20	0.35	0.073	0.093	0.25
38	Br	H	0.0063	0.12	0.36	0.019	0.067	0.29	0.078	0.065	0.29
39	I	H	0.033	0.044	0.084	0.025	0.16	0.12	0.15	0.16	0.27
40	SO₂Me	H	0.52	0.82	0.10	0.30	0.90	0.95	0.78	0.96	0.59
41	H	Cl	0.25	0.021	0.22	0.012	0.55	0.060	0.026	0.15	0.27
42	H	Br	0.33	0.037	0.56	0.013	0.67	0.15	0.0063	0.18	0.36
43	H	I	0.013	0.23	0.37	0.14	0.58	0.13	0.33	0.21	0.37

^a Abbreviations from columns left to right. CM: Cell morphology; CMI: Cell membrane integrity; ROS: Reactive oxygen species; GSH: Glutathione; NMI1: Nuclear membrane integrity 1; CC: Cell Cycle; NMI2: Nuclear membrane integrity 2; MMP: Mitochondrial membrane potential; CHI: Cell Health Index. ^b Traffic light colouring matching classifier values (Red–Green: high toxicity risk–low toxicity risk). ^c all n = 2.