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. 2023 Mar 8;24(6):5202. doi: 10.3390/ijms24065202

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the site of action of several current promising anti-TB drug candidates and hit/lead compounds. A simple version of the mycobacterial cell wall and the cytoplasmic membrane is portrayed, showing the current hot targets in TB drug discovery, namely GyrA/B, QcrB, ATP synthase, DprE1, FadD32, Pks13 and MmpL3. TMM: trehalose monomycolate, GroMM: glycerol monomycolate, TDM: trehalose dimycolate, GMM: glucose monomycolate (GMM), DPR: decaprenylphosphoryl-D-ribose, DPX: decaprenylphosphoryl-2′-ketoribose, DPA: decaprenylphosphoryl-D-arabinose, MAs: mycolic acids, FAS-I: fatty acid synthase I and FAS-II: fatty acid synthase II.