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. 2023 Mar 7;24(6):5093. doi: 10.3390/ijms24065093

Figure 3.

Figure 3

Uridine supplementation inhibited ferroptosis in murine lung via upregulating Nrf2-dependent antioxidant pathways and downregulating ACSL4 expression. (AC) Relative GSH, MDA and iron levels in murine lung tissue. (DF) Relative mRNA expression of SLC7A11, GPX4 and HO1 in murine lung tissue. (G) Western blots for NRF2, SLC7A11, HO1, ACSL4, GPX4 and ATCB (β-actin) in murine lung tissues. n = 6 per group. (Data are presented as Mean ± SD, ** p < 0.01, *** p < 0.001 compared with indicated group).