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. 2023 Mar 7;24(6):5093. doi: 10.3390/ijms24065093

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dysregulated uridine metabolism was confirmed in sepsis patients through meta-GEO datasets. (A) The volcano plot for differentially expressed genes in blood samples between sepsis and healthy control in GSE185263. Uridine metabolism-related genes were marked in the plot. (B,C) Relative UPP1 expression in GSE211210 and GSE137340, respectively. (D) Differential analysis of 28 immune-infiltrating cells according to ssGSEA analysis between UPP1 highly expressed and lowly expressed group in patients with sepsis. (E,F) The receiver operating characteristic (ROC) curve for diagnosing sepsis and predicting survival for patients with sepsis, respectively. (* p < 0.05, ** p < 0.01, *** p < 0.001, ns, no significance).