Skip to main content
. 2023 Mar 7;24(6):5082. doi: 10.3390/ijms24065082

Figure 3.

Figure 3

OxLDL/LOX-1 induces IL-6 secretion and STAT3 activation in CRPC cell models. (A) IL-6 ELISA assay from culture supernatants of C4-2B and 22Rv1 cells transfected with siRNA against LOX-1 or control and treated with 50 μg/mL oxLDLs for 24 h. (B) OxLDLs/LOX-1 induce the activation of STAT3 in CRPC cell models. Western blot analysis of p-STAT3 in protein extracts of C4-2B and 22Rv1 cells transfected with siRNA against LOX-1 or siRNA control treated with 50 μg/mL oxLDLs for 24 h. The data represent the means ± S.D. of three independent experiments analyzed by one-way analysis of variance and Dunnett’s post-test (*** p ≤ 0.001, ** p ≤ 0.01, * p ≤ 0.05, ns: non-significant statistical difference).