Figure 6. Schematic representation of subtle domain movements observed from apo to baccatin III- to 2a-bound curved tubulin.

The three structures were superimposed onto their central helices βH7 to highlight better the subtle domain movements relative to each other. The individual domains are colored according to their domain assignment and their borders are contoured using the same color scheme: N-terminal domain (N-domain, marine blue), intermediate domain (I-domain, orange), central helix βH7 (lemon), C-terminal domain (C-domain, red). The directions of the individual movements are highlighted with black arrows.