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. 2023 Mar 8;24(6):5176. doi: 10.3390/ijms24065176

Figure 3.

Figure 3

Graphical representation of the macrophage polarization phenotype of four treatment groups as described above. Proinflammatory polarization was observed in treatment groups challenged with either M. vaccae NCTC 11659 followed by RPMI 1640 vehicle or borate-buffered saline (BBS) vehicle followed by 250 ng/mL lipopolysaccharide (LPS) (as evidenced by IL10:IL12B, IL10:IL23A, TGFB1:IL12B, and TGFB1:IL23A ratios). An anti-inflammatory polarization was observed in the treatment groups challenged with M. vaccae NCTC 11659 followed by 250 ng/mL LPS. Abbreviations: IL-10, interleukin 10; IL-12, interleukin 12; IL-23, interleukin 23; LPS, lipopolysaccharide; PMA, phorbol 12-myristate 13-acetate; TGF-β1, transforming growth factor beta 1. Figure made with biorender.com.