Table 1.

Summary of articles that relate citicoline to glaucoma, classified according to administration route.

Author	Study Population	Citicoline Dose	Results
Topical instillation
Rossetti et al. [28]	Humans: OAG	0.2 g, 1 drop/day	↑ VF ↑ RNFL thickness
Parisi et al. [29]	Humans: OAG	2%, 3 drops/day	↑ pERG ↑ VEP
Roberti et al. [30]	Humans: OAG	2%, 3 drops/day	↑ pERG ↑ VEP
Oral solution/tablet
van der Merwe et al. [27]	Rats: GM	500 mg/day	↑ VA ↓ Histological alterations of visual pathway
Marino et al. [31]	Humans: OAG	Neuprozin®: citicoline (500 mg), homotaurine (50 mg) and vitE (12 mg).	↑ CS ↑ GQL-15
Chitu et al. [32]	Humans: OAG	600 mg/day	↑ VEP
Lanza et al. [33]	Humans: OAG	500 mg/day	↑ SAP ↑ VF ↑ RNFL thickness
Ottobelli et al. [34]	Humans: OAG	500 mg/day	↑ VF

CS: contrast sensitivity; GM: glaucoma model; GQL-15: Glaucoma Quality of Life-15; OAG: open-angle glaucoma; RNFL: retinal nerve fiber layer; pERG: pattern electroretinogram; SAP: standard automated perimetry; VF: visual field; VEP: visual evoked potential; VA: visual acuity.