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. 2023 Mar 10;24(6):5340. doi: 10.3390/ijms24065340

Figure 5.

Figure 5

Structural integrity of axons deteriorated by ONC was improved by treatment with GPR110 ligands. (A,B) Transmission electron microscopic images show cross sections of the optic nerves from sham and vehicle-, synaptamide- or A8-treated WT or gpr110 KO mice at 12 weeks after ONC (A), and the quantitation of the total axon number per field (B). Data are expressed as mean ± s.e.m. of the total 9 sections (3 sections per mouse) from 3 mice per group. (C–E) Electron microscopic images show the thickness of the myelin sheath of the axon fibers at 12 weeks after ONC (C) and the scatter plot for the g-ratio (the ratio of the inner to the outer diameter of the myelin sheath) as a function of axon diameter (D), along with the average g-ratio for the sham (blue), ONC + vehicle (grey), ONC + synaptamide (red) and ONC + A8 (orange) groups (E). Data are expressed as mean ± s.e.m. of the total 114 axons from 6 mice per group. *** p < 0.001. Scale bars, 2 μm (A) and 100 nm (C). n.s., not significant.